Self-reported Sexual Response in Transgender Women to Audiovisual Stimulation Protocol / Autoinforme de Respuesta Sexual en Mujeres Transgénero ante un Protocolo de Estimulación Audiovisual

Abstract Sexuality changes associated with the medical transition in transgender women are not well known; the few studies present discrepancies in labeling their sexual orientation and controlling surgery conditions. This study aimed to evaluate the self-reported sexual response to audiovisual sexual stimulation protocol in androsexual transgender women on hormone replacement therapy. This study also evaluated their sexual functioning to support the empirical protocol. Participated androsexual transgender women with (n = 16) and without hormone therapy (n = 15) in a non-sex reassignment surgery condition. Androsexual cisgender men (n = 25) and women (n = 24) also were included as contrast groups. All participants were assessed with the Short Form of the Changes in Sexual Functioning Questionnaire; then watched video clips with neutral and sexual content and informed their sexual responses through two self-report scales adapted from the Film Scale. The results showed trans women with hormone therapy, compared to trans women without treatment, experienced a less selective sexual response to sexual stimuli. Also, they registered the lowest scores for every sexual functioning except for pleasure. In conclusion, transgender women on hormone therapy without sex reassignment surgery showed fluidity in their self-reported sexual response and reduced sexual functioning.

Resumen Poco se conoce de los cambios en la sexualidad de las mujeres transgénero que se encuentran bajo un proceso de transición médica. El objetivo de este estudio fue evaluar el autoinforme de la respuesta sexual de las mujeres transgénero bajo terapia hormonal y sin cirugía de reasignación de sexo ante un protocolo de estimulación sexual audiovisual, así como el funcionamiento sexual general para robustecer los resultados del protocolo. Participaron mujeres transgénero sin cirugía de reasignación de sexo con (n = 16) y sin terapia hormonal (n = 15), así como hombres (n = 25) y mujeres (n = 24) cisgénero como grupos de contraste. Todas las personas que participaron reportaron una atracción androsexual. Se evaluaron con la Versión Abreviada del Cuestionario de Cambios en el Funcionamiento Sexual, posteriormente observaron videos con contenido neutro y actividad sexual entre dos mujeres, dos hombres y entre mujer y hombre, y reportaron su respuesta sexual a través de dos escalas de autoinforme adaptadas de la Film Scale. Los resultados mostraron que las mujeres trans bajo terapia hormonal, a comparación de las mujeres trans sin tratamiento, tuvieron una respuesta sexual menos selectiva, aunque esta fue similar a la de las mujeres cisgénero, además puntuaron más bajo para todos los rubros del cuestionario de funcionamiento sexual, excepto para el placer. En conclusión, las mujeres transgénero en terapia hormonal muestran fluidez en su respuesta sexual autoinformada, así como una disminución en el funcionamiento sexual. Estos datos pueden ofrecer un entendimiento más amplio del tratamiento médico y psicológico, con la finalidad de mejorar la atención a la población trans.

Caso Clínico: Transformación Angiomatosa Nodular Esclerosante de Bazo / Clinical Case: Nodular Sclerosing Angiomatous Splenic Transformation

Introducción: La lesión benigna de nombre transformación nodular angiomatoidea esclerosante de bazo, es una rara lesión descrita por primera vez en el año 2004, hasta el año 2017 apenas hay descritos 100 casos. Esta entidad ha sido reconocida como una lesión vascular no neoplásica esplénica de evolución benigna localizada en pulpa roja y secundaria a una exagerada proliferación estromal. La mayoría de los pacientes son asintomáticos, de diagnóstico incidental, la misma que se establece por Tomografía o Resonancia. El diagnóstico definitivo de esta patología se realizó mediante estudio anatomopatológico e inmunhistoquímica posterior a esplenectomía. Caso Clínico: Se reporta el caso de una paciente de 78 años, con diagnóstico incidental que se realizó fuera del instituto, que presenta resonancia magnética, cuyo reporte indicó tumor de 8 por 9 cm en relación al bazo y trombocitopenia en laboratorio. Microscópicamente, se trataba de una lesión bien delimitada, no encapsulada, formada por múltiples nódulos angiomatoides. Evolución: Actualmente la paciente en controles sin signos ni evidencia de recidiva tumoral, en controles en el departamento de cirugía digestiva. Conclusión: El SANT es una entidad vascular rara de características histológicas e inmunológicas específicas; formada por nódulos angiomatoidea constituidos por capilares, vénulas y sinusoides. Actualmente se le considera una lesión vascular no neoplásica esplénica de evolución benigna localizada en pulpa roja y secundaria a una exagerada proliferación del estroma. El tratamiento de elección de esta entidad histológica es la esplenectomía.

Introduction: The benign lesion, called angiomatoid nodular sclerosing spleen transformation, is a rare lesion described for the first time in 2004, until the year 2017 there are only 100 cases reported. This entity has been recognized as a splenic non-neoplastic vascular lesion of benign evolution located in red pulp and secondary to an exaggerated stromal proliferation. The majority of the patients are asymptomatic, of incidental diagnosis, the same one that is established by Tomography or Resonance. The definitive diagnosis of this pathology was made by anatomopathological and immunhistochemical study after splenectomy. Clinical case: The case of a 78-year-old patient was reported, with an incidental diagnosis that was made outside the institute, which shows magnetic resonance, whose report indicated a tumor of 8 by 9 cm in relation to the spleen and thrombocytopenia in the laboratory. Microscopically, it was a well-defined lesion, not encapsulated, formed by multiple angiomatoid nodules. Evolution: Currently the patient in controls without signs or evidence of tumor recurrence, in controls in the department of digestive surgery. Conclusion: SANT is a rare vascular entity with specific histological and immunological characteristics; formed by angiomatoid nodules constituted by capillaries, venules and sinusoids. Currently, it is considered a splenic non-neoplastic vascular lesion of benign evolution located in the red pulp and secondary to an exaggerated proliferation of the stroma. The treatment of choice of this histological entity is splenectomy.

Derechos y obligaciones de los usuarios del servicio de salud / Rights and obligations of users of the health service

Resumen: El principio de asistencia jurídica, en la calidad de la atención de los servicios de salud, son enunciados desde el carácter internacional en el Comité de derechos económicos, sociales y culturales, citado en el principio (d) la calidad debe ser la más apropiada posible, conforme a la ciencia y la tecnología en beneficio de la salud humana; consideración que la legislación nacional en materia de salud ha buscado respetar y replicar en las entidad federativas del país, con la idea de cubrir las necesidades de los ciudadanos y respetando la de sus instituciones.

Abstract: The principle of legal assistance, in the quality of health services, is enunciated from the international point of view in the Committee of Economical, Social and Cultural Rights; they are quoted in the principle (d) of quality that should be as appropriate as possible; according to the science and technology for the benefit of human health. The national legislation on health has taken into consideration the quality, trying to respect and replicate in the federal entities of the country, with the idea of being able to cover the needs of citizens and respecting its institutions in charge of the service.

An alarm pheromone reduces ventral tegmental area-nucleus accumbens shell responsivity.

2-Heptanone (methyl n-amyl ketone) is a ketone that produces alarm reactions in insects (e.g., bees and ants). As an olfactory stimulus, 2-heptanone produces anxiety reactions in the short term and despair in the long term in rodent models. Among the anatomical connections of the olfactory system that integrate behavioral responses, connections between the amygdala and nucleus accumbens are important, which in turn form a circuit with the ventral tegmental area (VTA). 2-Heptanone increases the firing rate of amygdala neurons without participation of the vomeronasal organ. The olfactory amygdala-VTA-nucleus accumbens circuit may integrate defensive behaviors, but the possible actions of 2-heptanone on the responsivity of VTA-nucleus accumbens connections have not yet been explored. In the present study, multiunit activity recordings were obtained in adult Wistar rats from the core and shell subregions of the nucleus accumbens during electrical stimulation of the VTA under basal conditions and later during simultaneous stimulation of the VTA and olfactory exposure to 2-heptanone. 2-Heptanone reduced the responsivity of the VTA-nucleus accumbens shell but did not influence the responsivity of the VTA-nucleus accumbens core. The lower VTA-nucleus accumbens shell excitability may be related to a primary defensive warning when exposed to an alarm pheromone.

On the MAC/network/energy performance evaluation of Wireless Sensor Networks: Contrasting MPH, AODV, DSR and ZTR routing protocols.

Wireless Sensor Networks deliver valuable information for long periods, then it is desirable to have optimum performance, reduced delays, low overhead, and reliable delivery of information. In this work, proposed metrics that influence energy consumption are used for a performance comparison among our proposed routing protocol, called Multi-Parent Hierarchical (MPH), the well-known protocols for sensor networks, Ad hoc On-Demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Zigbee Tree Routing (ZTR), all of them working with the IEEE 802.15.4 MAC layer. Results show how some communication metrics affect performance, throughput, reliability and energy consumption. It can be concluded that MPH is an efficient protocol since it reaches the best performance against the other three protocols under evaluation, such as 19.3% reduction of packet retransmissions, 26.9% decrease of overhead, and 41.2% improvement on the capacity of the protocol for recovering the topology from failures with respect to AODV protocol. We implemented and tested MPH in a real network of 99 nodes during ten days and analyzed parameters as number of hops, connectivity and delay, in order to validate our Sensors 2014, 14 22812 simulator and obtain reliable results. Moreover, an energy model of CC2530 chip is proposed and used for simulations of the four aforementioned protocols, showing that MPH has 15.9% reduction of energy consumption with respect to AODV, 13.7% versus DSR, and 5% against ZTR.

Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma.

PURPOSE: Paragangliomas of the head and neck are neuroendocrine tumors and are associated with germ line mutations of the tricarboxylic acid cycle-related genes SDHB, SDHC, SDHD, and SDHAF2. Hypoxia is important in most solid tumors, and was directly implicated in tumorigenesis over 40 years ago when it was shown that dwelling at high altitudes increases the incidence of carotid body hyperplasia and paragangliomas. Although recent research has now elucidated several pathways of hypoxia in paragangliomas, nothing is currently known of the genetics or of gene-environment interactions in high-altitude paraganglioma. We postulated that SDH mutations might play a role in these tumors. EXPERIMENTAL DESIGN: Patients from a Mexican family, originating and resident in Guadalajara, were tested for mutations of SDHD, and subsequently, for mutations of SDHB followed by immunohistochemical confirmation of SDHB loss. RESULTS: Two patients, born and resident at altitudes of between 1,560 and 2,240 m, were found to have head and neck paragangliomas, including a remarkably aggressive recurrent tumor. Mutation analysis identified a pathogenic missense mutation in exon 7 of SDHB, c.689G>A, p.Arg230His, and loss of the SDHB protein was confirmed by immunohistochemistry. CONCLUSIONS: This is the first report of a SDH gene mutation in paraganglioma at high altitude. A rapidly recurrent head and neck paraganglioma is a very rare finding in an SDH mutation carrier, suggesting a gene-environment interaction. Neither patient showed evidence of sympathetic paraganglioma.

Seminário Mídia e Saúde Pública, 3º, 2008 - debate dia 4/11 (manhã)

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Seminário Mídia e Saúde Pública, 3º, 2008 - Maurício Lara

A primeira análise que o jornalista faz sobre suas pesquisas é que a mídia oferece generosos espaços para uma abordagem da doença, falando da necessidade da conscientização do risco, das campanhas existentes, formas de prevenção e da divulgação de novas tecnologias e medicamentos. "Mas isso não significa que a imprensa ou a sociedade aprenderam como lidar com o doente", criticou. Segundo Maurício, muitas das campanhas pela conscientização da doença trazem uma linguagem inadequada, muitas vezes assustando ou ameaçando a pessoa, o que faz com que ela não queira descobrir se está doente. "A realidade é única: o câncer mata mesmo, principalmente se não há um diagnóstico precoce e um tratamento adequado. Agora, se a família e a sociedade não sabem lidar com o enfrentamento da doença, como podemos exigir que a imprensa faça o mesmo?", encerrou. Os arquivos estão disponíveis para leitura, audição e/ou download no ícone ao lado.